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It is usual to classify H1-antihistamines into two classes: old ones, called first-generation agents, which are sedating and recent ones, called second-generation agents which have slight or no sedating effects because they do not cross the blood-brain barrier.

In addition, each compound can have or not have parallel properties, antimuscarinic effects for example.

pharmacology of non sedating antihistamines-75pharmacology of non sedating antihistamines-20pharmacology of non sedating antihistamines-4

Antihistamines genrally come as tablets, creams, ointments and eye drops to reduce conditions such as watering, itchy eyes, running, itchy nose, sneezing, swelling and irritation of the eys, and to reduce hives, nettle rash and other allergic reactions.

Other H1-antihistamines having an important antimuscarinic activity like diphenhydramine and dimenhydrinate, are used in preventive and curative treatment of motion sickness, but scopolamine which has no antihistamine effect seems more effective than them in preventive treatment.

Bilastine is a new, well-tolerated, nonsedating H1 receptor antihistamine.

Bilastine is efficacious in all nasal symptoms including obstruction and in eye symptoms.

The observations indicate that non-sedating antihistamines, as opposed to what has been thought previously, may be helpful in patients with allergic rhinitis in whom nasal obstruction is a major concern.




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